首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   107299篇
  免费   3253篇
  国内免费   4706篇
系统科学   3755篇
丛书文集   3756篇
教育与普及   3970篇
理论与方法论   396篇
现状及发展   528篇
研究方法   300篇
综合类   102530篇
自然研究   23篇
  2024年   347篇
  2023年   1136篇
  2022年   1720篇
  2021年   1720篇
  2020年   1264篇
  2019年   496篇
  2018年   874篇
  2017年   1092篇
  2016年   1172篇
  2015年   2370篇
  2014年   3420篇
  2013年   3256篇
  2012年   3773篇
  2011年   4468篇
  2010年   4387篇
  2009年   4878篇
  2008年   5611篇
  2007年   5362篇
  2006年   4275篇
  2005年   4389篇
  2004年   3224篇
  2003年   3041篇
  2002年   3170篇
  2001年   3369篇
  2000年   3333篇
  1999年   5496篇
  1998年   4841篇
  1997年   4987篇
  1996年   4611篇
  1995年   3968篇
  1994年   3585篇
  1993年   3058篇
  1992年   2677篇
  1991年   2481篇
  1990年   2036篇
  1989年   1950篇
  1988年   1586篇
  1987年   998篇
  1986年   528篇
  1985年   179篇
  1984年   39篇
  1983年   16篇
  1982年   8篇
  1976年   4篇
  1974年   7篇
  1972年   5篇
  1971年   4篇
  1970年   4篇
  1969年   7篇
  1968年   6篇
排序方式: 共有10000条查询结果,搜索用时 140 毫秒
21.
为方便加工零件上不同位置的椭圆轮廓,采用坐标系平移与坐标系旋转的方法,将给定椭圆表达式所在的原坐标系与数控车床工件坐标系建立联系.并通过实例进行粗车循环与宏程序联合编程,完成零件加工.提出的坐标系平移与坐标系旋转方法,可方便地对不同位置的椭圆轮廓在数控车床工件坐标系中建立新的表达式,该方法数学计算简单,适用于各类、不同位置非圆曲线的宏程序编写.  相似文献   
22.
讨论二面体群的结构问题,利用GAP软件给出二面体群D2n的共轭类长素图,并完整给出当n以及n/2分别是奇数和偶数时的共轭类长素图情况.  相似文献   
23.
驱动桥壳轻量化设计对于提高承载能力、降低生产成本具有重要的意义.本文在驱动桥壳有限元分析和疲劳分析计算的基础上建立驱动桥壳多目标优化模型,对重型卡车驱动桥壳进行参数化设计,建立正交试验表,利用田口方法和综合评价方法对驱动桥壳的疲劳性能稳健性和质量进行优化设计.优化结果表明,此方法可以应用于驱动桥壳的多目标优化,优化后驱动桥壳的疲劳稳健性能得到提高,减轻了质量,因此节约了桥壳材料,降低了生产和运营成本,提高了设计水平.  相似文献   
24.
The record of paleo-environment in clayey aquitard pore water is much more effective relative to aquifer groundwater owing to the low permeability of clayey aquitard. Oxygen-18 (18O), deuterium (D), an...  相似文献   
25.
This paper studies the optimal investment problem for an insurer and a reinsurer. The basic claim process is assumed to follow a Brownian motion with drift and the insurer can purchase proportional reinsurance from the reinsurer. The insurer and the reinsurer are allowed to invest in a risk-free asset and a risky asset. Moreover, the authors consider the correlation between the claim process and the price process of the risky asset. The authors ?rst study the optimization problem of maximizing the expected exponential utility of terminal wealth for the insurer. Then with the optimal reinsurance strategy chosen by the insurer, the authors consider two optimization problems for the reinsurer: The problem of maximizing the expected exponential utility of terminal wealth and the problem of minimizing the ruin probability. By solving the corresponding Hamilton-Jacobi-Bellman equations, the authors derive the optimal reinsurance and investment strategies, explicitly. Finally, the authors illustrate the equality of the reinsurer's optimal investment strategies under the two cases.  相似文献   
26.
In order to improve the efficiency of 3D near-surface velocity model building, we develop a layer-stripping method using seismic first-arrival times. The velocity model within a Common Mid-Point (CMP) ...  相似文献   
27.

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.
  相似文献   
28.
A broker in an open e-marketplace enables buyers and sellers to do business with each other. Although a broker plays an important role in e-marketplaces, theory and guidelines for matching between buyers and sellers in multi-attribute exchanges are limited. Therefore, a challenge for a broker’s responsibility is how to maximize a buyer’s total satisfaction degree as its goals under the consideration of trade-off between a buyer’s buying quantity and price paid to a seller, and other attributes. To solve this challenge, this paper proposes an economic model-based matching approach between a buyer’s requirements and a seller’s offers. The major contributions of this paper are that (i) a broker can model a seller’s price policy as per a buyer’s buying quantity through communication between a broker and a seller; (ii) due to each buyer’s different quantity demand, a broker models a buyer’s satisfaction degree as per a buyer’s buying quantity based on communication between a broker and a buyer; and (iii) to carry out a broker’s matching processes, an objective function and a set of constraints are generated to help a broker to maximize a buyer’s total satisfaction degree. Experimental results demonstrate the good performance of the proposed approach.  相似文献   
29.
Au@Cu_2O core-shell nanorods with tunable thickness of Cu_2O shell were synthesized and their linear and nonlinear optical responses were investigated. Two transverse plasmon resonance peaks were observed when the Au nanorods were coated with Cu_2O shells, which were adjusted by the Cu_2O shell thickness. The nonlinear absorption of the Au@Cu_2O nanorods is enhanced by 5 times at the longitudinal plasmon resonance wavelength compared with that of bare Au nanorods. More intriguingly, largely enhanced nonlinear refraction and suppressed nonlinear absorption at the transverse plasmon resonance wavelength were observed in the Au@Cu_2O nanorods. Our findings indicate the existence of strong local field enhancement at the interface between the Au core and the Cu_2O shell, which would provide a promising strategy in designing plasmonic nonlinear nanodevices with good nonlinear figures of merit.  相似文献   
30.
Through molecular dynamics(MD)simulation,the dependencies of temperature,grain size and strain rate on the mechanical properties were studied.The simulation results demonstrated that the strain rate from 0.05 to 2 ns~(–1 )affected the Young’s modulus of nickel nanowires slightly,whereas the yield stress increased.The Young’s modulus decreased approximately linearly;however,the yield stress firstly increased and subsequently dropped as the temperature increased.The Young’s modulus and yield stress increased as the mean grain size increased from 2.66 to6.72 nm.Moreover,certain efforts have been made in the microstructure evolution with mechanical properties association under uniaxial tension.Certain phenomena such as the formation of twin structures,which were found in nanowires with larger grain size at higher strain rate and lower temperature,as well as the movement of grain boundaries and dislocation,were detected and discussed in detail.The results demonstrated that the plastic deformation was mainly accommodated by the motion of grain boundaries for smaller grain size.However,for larger grain size,the formations of stacking faults and twins were the main mechanisms of plastic deformation in the polycrystalline nickel nanowire.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号